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Here, the genes with high LPI values represent the core genes or genes with limited sequence variation.
The sequences in this clade show very limited sequence variation and we also have further evidence for NUMTS from the same species using different COI primer sets.
The limited sequence variation is isolated to the C-terminal amino acids leading up to and including 7 additional amino acids found in the Mgx proteins of strains K288 and 9117 (a human isolate currently being sequenced by Baylor College of Medicine Human Genome Sequencing Center, BCM-HGSC) which extend beyond the 495 amino acid Mgx protein found in strains 02161A and QMA0076.
Comparisons between different strains of E. tenella have found only limited sequence variation [ 18, 19].
Within the uninfected group was a further clade containing all individuals from Australasia and displaying very limited sequence variation.
For each gene, both A. aureum and A. speciosum exhibited limited sequence variation (see below for details).
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It was also found that some R genes/alleles from different donors differing by limited sequence variations conferred the same resistance spectrum by recognizing identical Avr genes.
Most studies illustrate that FMDV is a highly variable single-stranded RNA virus 13, 14, 18 that is genetically very diverse, but its variability can be lower than expected and vaccine escape mutants can arise through only limited sequence variations at several antigenic sites.
Because of this limited DNA sequence variation, routine genotyping of clinical MTBC isolates for epidemiological purposes relies on highly discriminatory DNA fingerprinting methods based on mobile and repetitive genetic elements.
However, the rarity of such alterations suggests a limited role for sequence variation in defining predisposition.
Specifically, the limited availability of sequence variation at the DRA largely affected our ability to predict the phylogenetic relationships among alleles and, thus, further examination of diversity in flanking regions of this locus would be useful for clarifying the mode of evolution occurring at this locus.
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