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The main limitations of cystoscopy are its limited sensitivity for flat lesions and its character as an invasive procedure potentially leading to significant discomfort for the patients [ 3, 4].
18F-FDG-PET without CT has demonstrated high specificity but limited sensitivity for detection of distant RCC metastases in older studies before the introduction of hybrid PET CT, providing an overall specificity and sensitivity of 100%andd 63.6%, respectively30.
Blue food coloring should not be used with enteral feedings due to its limited sensitivity for aspiration and some risk of mortality.
Noncontrast (35%) and contrast (64%) echo yielded limited sensitivity for thrombus on DE-CMR.
However, such IR detectors with traditional microbridge structures exhibit limited sensitivity for THz detection due to poor absorption of THz radiation [17, 18].
Up to date, the gold standard for clinical diagnosis includes invasive cystoscopy and non-invasive voided urine cytology with limited sensitivity for detection of low grade tumors [186].
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Although Rib-P antibodies have been known in some detail for more than 20 years, it may have been that the limited sensitivity of IIF for the detection of anti-Rib-P antibodies was the reason these aab were not included in the classification criteria of SLE [ 30].
The use of molecular gametocyte detection methods, unavailable at the time, would have improved our study as some of the exposure to gametocyte antigens in our cohort will have been missed due to the limited sensitivity of microscopy for detecting low density gametocytaemia [9], [42], [43], [44], [45].
The limited sensitivity of IIF for the detection of anti-Rib-P antibodies reported in this study might be attributed to a combination of different factors.
This is in line with the known limited sensitivity of SSH for isolating genes like transcription factors that are expressed at low absolute levels.
However, an important question to address is, to what extent albumin and sFLC changes may address the limited sensitivity of AFP for early HCC detection.
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