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The D2/D3 agonist radioligand [11C]--PHNO is currently the most suitable D3 imaging agent available, despite its limited selectivity for the D3 over the D2.
Dorsomorphin, which unlike endogenous BMP antagonists does not exhibit limited selectivity for ligand subtypes [20], can expand empiric efforts to modulate stem cell differentiation even in contexts where the specific cocktail of active BMPs is unknown.
Indeed, the only agents reported to target Mcl-1 to date are general transcription inhibitors, which show limited selectivity for Mcl-1 due to its short half-life.
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The DMAs III) signals were corrected for the limited selectivity of HG at pH 6 by spiking experiments when DMAs V) was found to generate with 5.0 6.8% efficiency without l-cys prereduction.
Due to low dispersion of CNTs into solvents and limited selectivity of CNTs and oxidized CNTs for SPE, a common technique is chemical functionalization which is used relatively often to generate functional groups on the surface of CNTs (Liu et al. 2008).
Given the limited selectivity of current small molecule tyrosine kinase inhibitors, studies of more selective antagonists are underway.
Furthermore, the study illustrates the importance and benefits of robust sample preparation and clean-up to compensate for limited selectivity when low-resolution MS is used.
However, despite of the high sensitivity exhibited for this application, LIBS suffers from a limited selectivity due to difficulties in assigning the molecular origin of the spectral emissions observed.
However, issues such as fouling, energy demand, and limited selectivity have been cited as reasons to disregard conventional membrane treatment for CR (Prakash and Sengupta, 2003).
In the case of the ZIP family of metal ion transporters, the name ZIP is short for Zrt-, Irt-like prothen—is the first indication of this limited selectivity.
At the best they are permitted a limited selectivity as consumers.
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