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Overall there was limited reversion observed in all subjects (11/207 revert to wildtype; Figure 1 and Table S3).
Patients in lowCD4BL were excluded as they showed limited reversion during STI.
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d) What is an IGRA "reversion" and what threshold should be used to define reversion?
While reversion is particularly prevalent in acute infection (Li et al., 2007), we show that reversion is not limited to early infection but happens throughout chronic infection.
The majority of U.S. states limit this conditional reversion to a specified length of a time, usually not longer than 50 years.
There is limited information regarding conversions and reversions of QFT-GIT test results among pulmonary TB patients and their household contacts in high TB burden countries.
Studies relying on reversion tester strains are limited by their inability to detect or determine multiple mutations in the same target gene as well as unlinked suppressor mutations, and the lack of strains to specifically detect G C to C G transversions (Prakash and Sherman 1973).
The QFT-GIT's utility for the application in serial testing was limited by a substantial proportion of reversions.
However, qualitative and quantitative reversion of a IGRA ELISPOT has limited clinical utility as a surrogate marker of treatment efficacy as it does not occur reliably in the majority of cured individuals.
As this does not occur reliably in the majority of cured individuals, qualitative and quantitative reversion of an IGRA ELISPOT has limited clinical utility as a surrogate marker of treatment efficacy.
In high TB burden settings, reports on QFT-GIT conversions and reversions among TB patients and their contacts are limited.
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