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We excluded meta-analyses of single common genetic variants, since these markers are known to have very limited prognostic ability when examined in isolation, 12 but multi-gene scores were eligible.
Due to an increasing incidence of MM and its poor prognosis, new prognostic and predictive biomarkers, preferably noninvasive, are needed, as previously described biomarkers, such as mesothelin and fibulin-3, have only a limited prognostic ability [ 29, 30].
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Numerous studies had observed the limited diagnostic or prognostic ability of urinary biochemistry [ 2- 6].
This study confirms the limited diagnostic and prognostic ability of urine testing.
In conclusion, Pons and colleagues' study is important because it confirms the limited diagnostic or prognostic ability of urinary biochemistry in critical care and also because it challenges the pre-renal AKI paradigm.
A comparative analysis of the 70-gene, 76-gene and the Gene expression Grade Index (GGI) signatures revealed that they have similar prognostic ability despite limited overlap in gene identity [ 64].
While RPPA analysis is useful for testing the prognostic ability of biomarkers on limited amounts of tissue, we set about validating these findings using IHC in an independent cohort.
The prognostic ability of this system is limited and as such other descriptors have been added.
Simple steatosis is generally considered to have a benign course and therefore to be of limited prognostic relevance2,3.
Rioux-Leclercq N, Karakiewicz PI, Trinh QD, et al. Prognostic ability of simplified nuclear grading of renal cell carcinoma.
However, only limited prognostic information exists regarding which patients are at greatest risk for pulmonary complications.
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