Many meta-analyses have been done for (1) and (3), but limited pooled results are available for (2).
Moreover, given the ecological nature of the disaster, the controls could not be selected from within the same area of the affected; hence we had two heterogeneous groups that limited pooled analysis.
"They have limited pools to distribute, but everybody still wants to reward their high performers," said Kathy Albarado, chief executive of Helios HR.
In [their] model, double-strand break (DSB) sites induced by IR interact with a limiting pool of DNA repair proteins, forming DSB-protein complexes at DNA damage foci.
A "no school, no pool" policy, to limit pool entry to students who go to school, played a key part in improving attendance rates at Areyonga, Santa Teresa and Yuendumu.
These gene dosage effects provide further evidence for the existence of a limiting pool of p300/CBP that may allow for differential p300/CBP recruitment depending on signaling pathway activation.
If both receptors competed for the same limiting pool of adenylyl cyclase, the combined effect of A1 and CB1 agonists would be less than additive.
Another clue is CBP haploinsufficiency, where one wild-type CBP copy is not enough for normal mouse development, and, conversely, CBP overexpression is also lethal in the fruitfly Drosophila melanogaster, indicating a tightly controlled, limiting pool of p300/CBP in cells.
A scarce and limiting pool of free ubiquitin has previously been suggested to explain the low abundance of ubiquitin monomers relative to multimers in mammalian cell culture studies[ 39].
Cross talk between NF-κB and p53 negatively regulates their activities by competing for limiting pools of the p300 and CBP coactivators, which are required by both NF-κB and p53 for transactivation (Webster and Perkins 1999).
