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Considering the overall outcome, the decellularization process leads to limited modifications of the treated tissues compared to native ones.
Alternatively, as suggested by the referee, it is possible that limited modifications of transporters encoded on the endosymbiont genome might modify a pre-existing molecular component to sustain essential exchange of metabolites.
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Hence it permitted to focus the redesign process on the critical groups in order to implement the desired machine upgrade by means of limited modifications to the current machine version.
Bloomberg suggests that they may be considering it because of some shady restrictions that Google has in place limiting modifications of the platform… even though Google is incredibly clear about any restrictions they have, and has openly denied that any other behind-the-scenes restrictions exist.
Considering the vast numbers of neutrophils that undergo apoptosis daily, it stands to reason that this immunologically silent cell death would also have evolved mechanisms to limit modifications of neighboring proteins.
At the present time, although original articles are limited, epigenetic modifications of SLC6A4, BDNF, and IL11 genes are showing promising results as biomarkers for prediction of antidepressant response.
Epigenetic fetal programming is limited to modifications of the epigenome of the developing offspring, primarily targeting somatic cells that are responsible for tissue-specific gene expression.
Although the double-antigen sandwich ELISA has its advantages, the applicability has been limited because of modifications to the antigenic structure caused by chemical conjugation.
While the mechanism of how c-Myc functions in such a cell context-dependent manner is not clear, possibilities include, but are not limited to, post-translational modifications of c-Myc.
We also have limited knowledge of chromatin modifications taking place at genes whose transcription has been down-regulated.
However, attempts to improve the effectiveness of PA should not be limited to the modification of the PA tool.
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