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Both the traditional and molecular activity assessments indicated that free ammonia had a limited inhibitory effect on Nitrobacter spp. In fact, the pH changes necessary to induce high free ammonia concentrations (>10 mg-N/L) had a demonstrably more important inhibiting effect on nitrite oxidation than free ammonia.
One possible explanation for the limited inhibitory effect of the SOFA-HDV ribozyme against HCV strands might be the fact that the replication complex is compartmentalized by a lipid bilayer membrane [32], [44] [45].
Gentamicin is a type of aminoglycoside antibiotic that acts on ribosomal 30S subunits in bacteria, inhibiting the protein synthesis and damaging the integrity of the cell membrane, but it has a limited inhibitory effect on M. pneumoniae.
Treatment with α-mangostin at concentrations of more than 8 μM significantly reduced the viability of both cancer cell lines in a time-dependent manner (P < 0.05) and 1(b)); however, limited inhibitory effect on hTERT-HPNE cells was observed).
Similarly, we found that α-mangostin inhibited the proliferation and induced apoptosis of pancreatic cancer cells in a time- and dose-dependent manner, but limited inhibitory effect on the normal human pancreatic ductal epithelial cell was observed.
In the present study, we demonstrate that TFM-C inhibits innate immune cells and animal models of arthritis, including CIA and type II collagen antibody-induced arthritis (CAIA), in contrast to the limited inhibitory effect of celecoxib.
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Kanamycin plus neomycin, trimethoprim and 5-fluorocytosine exhibited limited inhibitory effects.
DMNQ has an optimal redox potential of −183 mV for redox activity (thereby replicating the favored mechanistic hypothesis for DOX), and causes cardiotoxicity, but unlike DOX has only limited inhibitory effects on DNA replication and transcription.
While the majority of these studies point to the vulnerability of the reproductive success following food-deprivation in females, limited studies have revealed inhibitory effect of food-deprivation in males.
However, based on our data, it appears that inhibition of uncontrolled cell cycle progression plays a limited role in the inhibitory effect of capsaicin on KB cell growth.
Due to irreversible COX-1 inactivation and the fact that platelets have limited capacity for de novo protein synthesis, the administration of low-dose aspirin every 24 h causes a complete and persistent inhibition of COX-1 in platelets associated with a limited and rapidly reversible inhibitory effect on COX-2 expressed in nucleated cells (Patrono et al., 2008).
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