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However, a lack of prospective research has limited hypotheses regarding the temporal relationship between trauma exposure, ERD, and PTSS.
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17 Therefore we limited hypothesis testing in this study to one prespecified subgroup analysis and we make our data extraction forms reflecting all collected variables available to readers on request.
Increasing the size of prospective cohorts and biobanks is one approach to discovering previously unknown contributors to complex diseases, but it may come at the price of concealing contributors that are less common across all the participants in those larger studies and of limiting hypothesis generation.
The number of hypotheses is not limited; any hypothesis may be examined provided there are enough exposure measurements to identify it.
To avoid confusion about scientific validity of the results, it is also intentionally limited to hypothesis exploration without hypothesis testing.
First, constrained topology searches and SH tests were carried out using RAxML v. 7.7.8, which was limited to hypotheses that require positive constraints (Table 2).
Yet while Baer's [ 42] study presents a broad outline for understanding H. formosa historical biogeography, the limited levels of genetic variation he found and the more modest methods available at the time limited the hypotheses that could be tested.
Embedded in practice, innovations were often based on engineering intuition; their rationale was developed later, sometimes limited to hypothesis.
It was performed as an observational study; thus, the results should be limited to hypothesis deriving.
Under the IDEAL framework, use of retrospective studies should be limited to hypothesis generation in the earliest stages.
Moreover, the use of a voxel-based analysis allows investigation of the whole brain and is not limited to hypothesis-based predefined regions.
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