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It is more accurate than CT, which has limited grading accuracy and utilizes ionizing radiation.
Pain limited grading of the weakness; however, mobilization was possible.
We attempted to reduce this error by defining a standardized location for the measurement of each muscle; however, this partially limited grading to a single section of the muscle.
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Neurotoxicity was limited (grade 1 2) and did not require treatment discontinuation.
In addition, the scientific foundation is limited (GRADE level 2, low quality of evidence).
The panel proposes to narrow the gap as a way of resurrecting the respectability of a B and, ultimately, of limiting grade inflation.
Severely disabling chronic pain was defined as pain within the last six months that had lasted for three months or more and was highly disabling-severely limiting (Grade IV).
Dose limiting grade 3 or 4 diarrhoea was reported in seven out of 57 patients, three at the 20 mg m−2 dose level.
Pain severity can be graded in four hierarchical classes (Grade I, low disability – low intensity; Grade II, low disability – high intensity; Grade III, high disability – moderately limiting; Grade IV, high disability – severely limiting).
This is a 7 item questionnaire resulting in four hierarchical categories: Grade I, low disability - low pain intensity; Grade II, low disability - high pain intensity; Grade III, high disability - moderately limiting; Grade IV, high disability - severely limiting.
Although a reduction of administration of gemcitabine was needed in two-thirds of the patients in this study because of grade 3 or 4 neutropenia, it was possible to limit grade 3 or 4 neutropenia during all cycles to 18% by reducing the quantity of administration of gemcitabine in subsequent cycles.
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