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So far, humanized mouse models based on the transplantation of human HSC only – i.e. without additional human tissues – share these limitations, and immunization strategies result in the limited generation of class-switched antigen-specific B cell responses [14], [31], [32].
The success of the vaccination strategy using whole Gag-expressing vectors resulted in limited generation of immune escape at the KP9 Gag CD8 T cell epitope.
The possible scenarios which could explain this phenomenon include: an antibody-dependent cellular cytotoxicity (ADCC), a complement-mediated lysis, an impairment of the survival through prevention of BAFF binding or a limited generation of newly formed mature B cells as a consequence of the depletion of transitional B cells.
Complex I presents low NADH dehydrogenase activity, justifying the limited generation of superoxide observed in T. brucei procyclics and T. cruzi epimastigotes [ 58, 66].
Despite this rise in donor funding and increasing allocations within national programs, there exists considerable shortfall of external funds[ 36] and a limited generation of local resources, making efficient allocation of finances necessary.
Despite having potentially pivotal pleiotropic roles in glycemic regulation and T2D, there has been limited generation of stable animal models for the investigation of PANDER function, and there are no models on well-established genetic murine backgrounds for T2D.
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Recently, limited generation capability of conventional thermal power plants due to shortage in fuel supply in addition to the rapid increase in load demand resulted in repeated and prolonged load shedding all over the country.
All-electric ship power systems have limited generation and include a large portion of nonlinear loads and dynamic loads relative to the total power capacity.
Population-based phasing methods are probabilistic, limited to generation of short haplotype blocks, and will incorrectly phase rare combinations of variants, exactly those combinations most likely to be medically important.
Constraints can essentially be defined as the limited or channeled generation of variation (Maynard Smith et al. 1985).
While this is an effective approach for disrupting gene function, it is stochastic and limited to the generation of indels.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com