Current diagnostic thresholds for diabetes mellitus have limited sensitivity for identifying individuals with these microvascular complications.
However, the CO1 gene and other mitochondrial genes from plants have limited usefulness for identifying plant species across a wide range of taxa due to the low amounts of variation in the genes, as well as the variable structure of the mitochondrial genome [9], [13] [16].
Biomarkers, whether in serum, urine, or exhaled breath, have found limited use for identifying and quantifying postoperative lung injury.
Although this method is effective at identifying SINE polymorphisms in the genome reference, it has limited use for identifying polymorphic insertions in taxa lacking a reference genome.
The current analysis extends this prior finding and indicates claims data have limited usefulness for identifying individuals with a Framingham 10-year CHD risk score >20%.
Because the present study was shown to have limited power for identifying genetic risk factors with small effects we designed the interaction analysis without partitioning the GAIN sample into a testing and replication datasets.
For instance, although PathBLAST [ 20, 22] can implement query searches, it is mainly only applicable to small pathways – up to 5 proteins – mainly due to the dimensionality problem with pathway length, and has limited support for identifying non-exact pathway matches.
These web-based tools are useful in predicting candidate sites in cases where a kinase protein substrate relationship has been established in vivo, but they suffer from over-prediction and therefore have limited usefulness for identifying phosphorylation sites with physiological relevance.
A limiting factor for identifying citations is related to late indexing of journals in electronic databases.
Despite the availability of this new mapping method and the larger mapping population, marker density remains an important limiting factor for identifying genes controlling quantitative traits.
