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B149 had some impairment in the rate of cell-to-cell movement (foci diameter of 2.72 cells versus 3.88 cells in parental genotype) as early as day 2. While the limited foci that formed on B149 expanded slowly and stopped expanding after a few days, foci on C24 continued to expand rapidly (Figure 4 and Figure 3-Panels B and C).
These authors have concluded that the previously observed amplification frequency could have been overestimated by scoring as amplified some tumors with only very limited foci of amplification.
Also, as many urologists actively seek patients with organ-confined disease, an increasing proportion of biopsies is performed in younger, asymptomatic patients with low serum PSA, so that the diagnosis of carcinoma is more often made on limited foci.
Although a similar staining pattern is observed in E8.5 and E9.5 PGCs, intense 5hmC territories are observed in E10.5 and E11.5 PGCs, and the intense 5hmC is further restricted to limited foci in E12.5 and E13.5 PGCs.
It is not clear if these analyses were done in a blinded manner, whether limited foci of amplification were used to call positivity, or if these differences are due to heterogeneity.
It aims to identify high risk areas or groups, monitor progress of polio status, indicate the need for supplementary strategies if widespread outbreaks occur or "mopping-up" immunization if restricted to limited foci, as well as to certify a country polio-free.
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Offering the most extensive defence yet on the efficacy of secret surveillance programs reported by the Guardian and the Washington Post, Alexander said they were "limited, focused and subject to rigorous oversight".
Each approach provides advantages that are useful in designing mirrors to achieve diffraction limited focusing.
Nevertheless, it seems obvious that diffraction limited focusing from more than half of the hemisphere would produce a smaller three-dimensional focal volume.
The response of the West, Nato, the EU - however you want to label it - has been limited, focused on the short term and profoundly political rather than genuinely strategic.
Government policy measures to improve sanitation are limited, focusing only on urban areas.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com