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Likewise, for human influenza A viruses, mutations on side branches have limited effects with regard to producing antigenically novel variants.
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Opinion polls suggest the pounding is having only a limited effect, with the Brexiteers snug in their positions and largely oblivious to the ordnance being rained down on them.
Finally, as we observed a limited effect with the early treatment of Rpe65-/ Rho-/ mice compared to the study of Pang et al. (2010) [18], we may also have to improve our protocol in order to increase the dose of RPE65 re-expression to allow a functional cone recovery in these models.
Current drugs that target growth factors, however, like the anti-angiogenic drug Avastin, have a limited effect, with only a few months of overall survival extension (Amit et al. 2013).
Long-term treatment with albendazole has a particularly marked effect on the cysts (Morris et al., 1990; McManus and Smyth, 1986), while long-term treatment with praziquantel only has a limited effect with few changes in the germinal layer of the cyst.
Transmission-blocking drugs have only limited effects unless administered with a prophylactic under very high coverage.
Renal cell carcinoma (RCC) is the predominant form of kidney cancer, and systemic therapy using cytokine or cytotoxic agents provides limited effects to RCC with distant metastasis.
Anti-ICAM-1 (intracellular adhesion molecule-1) monoclonal antibodies have been evaluated in a phase I/II open-label study and had only limited effects in patients with RA [ 37].
Earlier models were deficient in that only microphase action was considered with limited effects of nucleation.
We find that the wheat policy has generally benefitted flour consumers and wheat traders at the expense of wheat farmers, with limited effects on flour millers.
Lower blood pressure goals and more intensive antihypertensive therapy appear to be well tolerated with limited effects on patients' perception of health status.
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