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56 Overall, a marginal positive effect of sulfasalazine with a rather limited effect size in AS cannot be excluded.
However, caution is needed before generalize the results of these studies because the limited effect size and deficient methodologies [ 13].
These might be additional common variants with very limited effect size, or rare variants with a higher effect size.
Coupling this limited effect size with the fact that for most genes no more than a tiny fraction of the variation has ever been tested, it is clear that few if any genes have received a thorough analysis.
Such sources may include common variants with limited effect size, rare variants with higher effect sizes, structural variations, or even more complicated mechanisms such as epistatic, gene-environment and epigenetic interactions.
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The research specifically aimed to determine whether a low-cost intervention with a limited intervention effect size, such as that evidenced by the recent meta-analysis on the effectiveness of such interventions [ 6], would prove cost-effective for implementation across the general population through primary health care services.
The issue of limited study power due to the small effect size and limited sample size should be noted.
We did not weight the risk alleles on the basis of their individual effect sizes because it has been shown that weighting of risk alleles may have only limited effect [21] and because the effect size of SNPs on traits at baseline may not be relevant to the effect on the change in trait.
It is noted that EOF has a limited effect when the channel size is larger than 1 μm due to the fact that EDL is usually very thin (in the order of nanometers).
Third, they also strengthen the ability to evaluate the 'common disease, common variant' hypothesis by demonstrating a common direction of effect for risk-associated alleles across populations when power or effect size is limited [ 29].
Although it would take a large study with a strongly positive result to cause a noticeable increase in effect size, the limited number of studies and relatively low overall numbers of participants could reduce the robustness of our findings, and as results from further studies become available it is important that this analysis is updated.
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