HITS can provide an accurate and uniform treatment dose in the skin with limited doses to OARs and is safe to replace a total skin electron beam regimen.
However, by properly designing the treatment plan with the increasing availability of advanced treatment techniques, plans possessing a concave dose distribution with limited doses to the critical heart, lung, and contralateral breast organs should be achievable.
SIB is explored earlier for other cancers [ 5– 9], showing a good coverage of the boost region, with limited dose spread to the surrounding tissues and without excess of dose to the organs at risk (OAR).
The aim of radioimmunotherapy (RIT) is to selectively target radioactivity to tumor lesions, with limited radiation dose to healthy tissues.
For safety evaluation, traditional animal toxicological studies with long-acting insulin analogues are hampered by limited dose ranges due to premature animal death from hypoglycaemia at higher doses, such that the emphasis has shifted to molecular characterization of insulin analogues in pre-clinical studies (19, 22, 23).
Analysis of the slopes of the AUC revealed that this was not a good parameter to use for analysis of dose responses, since these slopes were not significantly above 0, suggesting limited dose responsiveness in AHR to HDM exposure.
Hence, it cannot be concluded that the CRT combination evaluated here provided a greater activity than either agent alone due to limited dose escalation.
At the individual level, the existence of a lower threshold is perhaps not surprising, on the simple assumption that people are able to absorb a limited dose without detectable adverse effects.
A limited dose however will limit the therapeutic index of given anticancer drugs.
Limited dose warfarin (LDW) throughout pregnancy was suggested to provide safe and effective anticoagulation in pregnant patients with mechanical heart valve prosthesis (MHVP).
