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While I was confident in my analysis, I had concluded much of this through intuition and connecting the dots from admittedly limited data points.
There were limited data points upon which to base a sound estimate.
For this reason, we have tried to explore alternative ways of obtaining average unit costs for cost-effectiveness analysis aimed particularly at countries where there are limited data points available from accurate costing studies.
The dosimetric calculations were performed with limited data points, which limit the confidence in the data curve-fitting for determining the time-integrated activity coefficients in source organs.
However the limited data points along with their associated uncertainty mean that we cannot entirely rule out either possiblity.
Second, with the limited data points, we were unable to create separate datasets for model building and model validation.
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Although the step was admittedly a small one, even these limited data point to curious differences in distribution of CO and GC events, a bias against COs occurring in exonic regions, and a motif enriched in the vicinity of CO events.
Such in vivo experiments are, however, cost intensive and generate often only limited data end points as mice have to be killed to assess damage in the intestinal epithelium using histology or histochemistry.
Because > 99% of the samples gave a value > 0 for TBARS and 8-isoprostane, and most of them were above the detection limit, data points below the detection limit were not given special treatment.
The NCS will collect an array of biospecimens, dietary and physical activity data, and social and chemical environmental factors on all 100,000 children for all proposed data collection time points, whereas other cohorts have collected more limited data at each time point or collected complete data on a smaller sample.
There are limited data on surrogate end points, with evidence of benefit in carotid intima-media thickness in the Troglitazone in Prevention of Diabetes (TRIPOD) study with troglitazone (56) and in the STOP-type 2 diabetes study with acarbose (57).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com