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If α is low, each FAP is included in large number of active sets and all users connected to this FAP must share the limited backbone.
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The vertebrae are connected by tight joints, which limit the backbone's flexibility.
Although TIMPs are compact molecules that display only limited conformational flexibility, backbone movement of TIMP-1 has been reported upon binding to MMP-3 [ 35].
Molecular dynamics and even relatively inexpensive techniques [ 6] are able to consider more complex changes of the polypeptide backbone; typically, scanned are only conformations of amino acid side chains, and changes of the polypeptide backbone are limited or not allowed altogether so that larger rearrangements of the interacting molecules are hard to predict.
The polymers thus obtained have limited conjugation through the backbone.
The newly defined scoring function is not limited to just the backbone carbonyl oxygen.
The FAPs' backbone is limited to 8 Mbps for downlink and 50% of its capacity is supposed to be occupied due to ADSL aggregation and signaling overhead.
Perhaps intercalation of TO upon hybridization of the 13mer to KRAS2 RNA created excess strain on the ribose-phosphodiester backbone, limiting the achievable fluorescence quantum yield upon hybridization to RNA.
Originally, the protein backbone motion is limited to normal modes obtained by the anisotropic network model (ANM), a pure theoretical approach based on a distance matrix.
Furthermore, the phosphodiester backbone of the RNA DNA hybrids used in this study is of a greater physiological relevance than CpG phosphorothiorate ODNs whose correspondence to natural ligands is limited both by strandedness and backbone structure.
Linear motifs that use mostly side chains for binding may be amenable to interactions in opposite orientations but those that make extensive contacts using their backbones may be limited to a particular orientation.
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