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A phase II study in adult patients with chronic lymphoid leukemia indicates that monotherapy with Ibrutinib might be effective even in high-risk cases with limited adverse effects.
If magnesium sulphate is found to be effective in preventing post-ERCP pancreatitis, this inexpensive agent with limited adverse effects could be used as a routine pharmacological prophylaxis.
In her review she summarizes the pleiotropic anti-inflammatory properties of VDRs with potentially limited adverse effects.
Several PARP inhibitors are currently under clinical trials for advanced breast and ovarian cancer, giving good objective response rates and limited adverse effects (Tutt et al. 2010).
Zebrafish embryos immersed in DDT between 6 and 30 hpf showed limited adverse effects to the organochlorine after completion of neurodevelopment (7 dpf).
By escalating the treatment dose, a maintenance dose can be reached that is far higher than the maximum tolerated dose at onset, with limited adverse effects.
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46 The dose-limiting adverse effect in this study was transient and self-limited, orthostatic hypotension.
We want treatments that improve the patient's chances at low cost and with limited adverse side effects and we want to avoid "cures" that might be worse than the disease.
Limited systemic adverse effects and physician-administered treatments that eliminate concerns for patient compliance have made onabotulinumtoxinA an appealing alternative to oral prophylactic medications for migraine.
Thus, the study is expected to result in limited risks, adverse effects and discomfort to the participants.
Another important limitation of the clinical mapping function is the limited set of adverse effects of antipsychotic treatment accounted for in this model.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com