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SPECT analysis of the total body and thyroid counts showed a limited accumulation of 125I within the body.
This limited accumulation of PR1a transcripts could be due to wounding during leaf excision.
This sequence of events may explain the relatively limited accumulation of mutations observed during this outbreak.
Hence, for these compounds C E/C P is fixed at zero, indicating very limited accumulation of these compounds in the erythrocyte.
Interestingly, despite high levels of hyperphosphorylated and pre-tangle tau accumulation there is extremely limited accumulation of oligomeric tau (as detected by TOC1 antibody) [ 19].
Therefore, the low level of differentiation may be better explained by limited accumulation of drift due to recent divergence and large N e 's.
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Another plausible explanation for the tolerance in this accession is presence of root specific tonoplast transporters with some accessory factors associated with the genes for providing energy to transport ions into vacuole but with limited accumulation capacity of ions in vacuole.
Biodistribution studies show that there is negligible radioactivity in all non-tumor tissues sampled, with the exception of the thyroid gland, where limited accumulation was observed (0.06% of injected dose after 7 days).
Since clinical experience of pancreatic PEComa is very limited, the accumulation of this disease's reports is required to define the worrisome features as an indicator of recurrence and metastasis of pancreatic PEComa, and since the tumor can recur, we recommend complete resection and careful follow-up.
Unlike the mutation of ΔH16_A0384, the deletion of H16_A2203 (HPr-related phosphocarrier protein), frcACB (fructose-specific ABC-type transporter) or nagFEC (PTSNag) could not enhance the growth and limited PHB accumulation of the derived multiple mutants H16 ΔptsH ΔH16_A2203, H16 ΔptsMHI ΔfrcACB and H16 ΔptsMHI ΔnagFEC.
These results emphasize that while limited cellular accumulation of a drug is an important mechanism of drug resistance, if there is a trade-off between uptake into proximal cells and penetration to distal cells, therapeutic effectiveness may be limited, especially for drugs like doxorubicin that have a short half-life in the circulation.
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