In E. coli, RelA is associated with the ribosomes and senses the binding of uncharged tRNAs (during amino-acid limitation), upon which the synthase activity of RelA is induced [ 174, 180, 181].
In using such curve fits, caution should be maintained to recognize the limitations of the data upon which the curve fits are based: the nanofluids used a 0.25 wt% of gum arabic, and the MWCNT concentration was fixed at 0.5 wt%.
Note that the majority of the gene structures generated by GeneSeqer were expected to be partial; reflecting the 5' limitation of the ESTs upon which they were based.
They also emphasize the limitations of the indirect data upon which clinical strategies are based.
Together, these factors underline the limitations of the knowledge base upon which palliative care has to draw.
It is important to place our results within the context of a methodological limitation, namely that the survey upon which our findings were based was cross-sectional.
Limitations of the currently available evidence upon which the recommendations are made must be recognized.
A new framework, the 'behaviour change wheel', was designed [ 7] in order to address the limitations of existing behaviour change frameworks, upon which many lifestyle interventions are based.
There are several limitations of this study, most important being the above-mentioned assumptions, upon which the evaluations were based.
As such, a strategy was developed to expand DSSTox by adding data available from publicly available data sources, while also controlling for the limitations of those sources and preserving the aspects of quality curation upon which DSSTox was built.
