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Limitations: Unclear if the Broselow tape was used or if derived from length measurements.
Efficacy of adjunctive CLB in refractory focal epilepsy was assessed only in a small double-blind, randomized, placebo-controlled, cross-over study hampered by several methodological limitations (unclear allocation concealment, generation of random sequence and method of blinding) [ 14].
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Other potential limitations include unclear sequence generation, unclear allocation concealment, and a very high dropout rate in some of the included trials.
Important study limitations include unclear adequacy of sequence generation, unclear allocation concealment, single blinding, and lack of intention-to-treat analysis.
While numerous algorithms have recently been proposed for analysing the large ChIP-seq datasets, their relative merits and potential limitations remain unclear in practical applications.
42 Other limitations include unclear dose-response effects below about 0.5 Gy, inadequate information about possible biological mechanisms, and uncertainty about the generalisability of these results to Western populations because of differences in genetic factors, dietary and lifestyle risk factors, and baseline levels of risk for stroke and heart disease.
Although FEV1 remains the gold standard for staging COPD, the association between airway remodeling and airflow limitation remains unclear.
Although the reason for this limitation remains unclear at this stage, considering the excellent qualitative agreement obtained with polarization chaos features, we are convinced that these dynamics have the same origin.
Consequently their role in the response to iron limitation is unclear.
Second, the cut point that should be used to identify physical function limitation is unclear, ranging from ≤ 7.24 seconds [ 18] to ≥ 14 seconds [ 17] in several published studies.
The impact of this limitation is unclear but the authors do note that the average baseline laboratory and clinical values for the subset of patients with follow-up data were similar to those of the baseline values for the entire sample.
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