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Limitations: Trial designs were heterogenous and patient number was limited.
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Although cross-study comparisons have severe limitations, trials evaluating the sequential approach report a hazard ratio ranging from 0.57 to 0.76, while the upfront approach results in a hazard ratio of 0.82 0.87.
1 2 Other reasons that hamper the generation of valid results from trials are limitations in trial methodology and reporting of trial results.
Limitations: Clinical trial data have limited applicability to clinical practice.
What are the functions and limitations of trial?
Limitations: Open trial, retrospective design and small sample size.
In this Review we discuss the measurement, assessment, and benefits and limitations of trial endpoints in use for cancer treatment.
Limitations in trial reporting constrain conclusions about longer duration of analgesia and adverse event profile.
Limitation: Open trial.
LIMITATION: The trial was not designed to detect differences in these subgroups.
Study answer and limitations Twenty four trials (4880 patients), including seven interventional treatments, were identified.
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