Considering the substantial morbidity, mortality and costs associated with pneumococcal disease as well as the limitations of Markov models to simulate the dynamics of transmissible disease, there is a need for more accurate models as soon as valid effectiveness data of PCV13 is published to confirm the cost-effectiveness of this vaccine.
Nishikado, however, was not satisfied with the enemy movements; technical limitations made it difficult to simulate flying.
Alternatively, the Monte Carlo (MC) method is considered an accurate light propagation model without any of the limitations of the DE to simulate pulse propagations in diffuse media [ 23].
There is low confidence in projections of small spatial-scale phenomena such as tornadoes and hail because competing physical processes may affect future trends and because of limitations in climate models to simulate them.
Limitations include the inability to simulate changing respiratory system compliance, such as during CPR, and the nonsignificant (37 s versus 55 s) difference in insertion time between the LMA and the combitube.
While an artificial-intelligence system like Watson can produce some striking connections, it nevertheless embodies a decisive limitation as it seeks to simulate human problem-solving performance: it begins by using logic.
Three nonlinear numerical models, all of which can avoid the limitation, are then established to simulate the membrane's large deformations, including the membrane model with zero bending stiffness and the shell model with small but nonzero bending stiffness based on the latest Edge-based Smoothed Finite Element Method (ES-FEM) as well as the standard Finite Element Method (FEM).
In order to simulate nutrient limitations, cells were centrifuged prior to infection and ressuspended in a 1 1 dilution of conditioned medium with PBS buffer (adjusted to pH 6.1 and 370 mOsm).
However, because of length and time scale limitations, it is not currently possible to simulate the entire crystalline cellulose degradation process using all-atom MD simulations.
As for IM2, the resonance appears because the limitation of the adjacent blades is weakened due to their inertia effects, however, the resonance does not appear because of the strong limitation of the springs used to simulate adjacent blades for IM1.
