In order to quantitatively validate this difference and to observe the limitations of the CT, we compared the spatial extent of uptake regions from PET and the anatomical correspondences of those regions from MR or CT by manual delineations provided by two expert clinicians (blinded to their drawings).
Linkage studies on late-onset AD have suffered similar limitations to those observed in association studies.
While this is the case in the general adherence literature, these limitations make it difficult to observe patterns of adherence and limit generalizability for Brazil as a whole.
Despite these limitations, it is encouraging to observe a high correlation with these datasets.
However, physical, affective, cognitive, or social limitations are sometimes hard to observe.
Despite these important limitations, we were able to observe statistically significant associations between 8-OHdG and 1-OHPyr after 6 h of work.
For instance, there are only 602 molecules of a fluorescent reporter at 1 µM in a femtoliter, so if these are excited at photodamage-limited intensities [9], [10] there are very few photons per unit time emerging from the focal spot, making shot noise a severe limitation on the ability to observe small, fast changes.
Despite these limitations, the authors were able to observe that, with this protocol design, manual therapy followed by active exercises was efficient on various patients with CNSLBP.
As a further limitation, these studies were planned to observe differences in attendance rates, not in CIN yields.
