Some of the indirect costs of asthma include absence from work and school, activity limitations, sleep disturbances, and at its most extreme, death.
Secondary end point domains (physical limitations, sleep and energy, severity [coping] measures, and symptom severity) were also significantly improved (p ≤ 0.006) after treatment with Tolt-ER.
The secondary outcomes of the study are quality of life, functional limitation, sleep, global improvement with treatment, and protocol adherence.
The RQLQ has 28 questions in 7 domains (activity limitation, sleep problems, nose symptoms, eye symptoms, nonnose noneye symptoms, practical problems, and emotional function) and each question was scaled from 0 (not impaired at all) to 6 (severely impaired).
A possible limitation of our study was that SDB was characterised using home unattended limited sleep studies rather than in-hospital attended full polysomnography.
Potential limitations of sleep research in children are discussed, specifically the loss of research precision inherent in sleep deprivation protocols involving children.
This was due to the intrinsic technical limitations of sleep recording for the whole night with high-density EEG.
Although activity limitations and sleep disturbances might also be considered as assessing impact, the study team, influenced by the weight of the evidence in the literature, theorized that, in the case of asthma, symptom severity may be expressed in terms of their impact.
The original CAT designed to assess current health status has 8 items covering cough, phlegm, chest tightness, breathlessness, activity limitation, confidence, sleep, and energy.
Chronic pain has a wide-ranging impact on daily life and activities [ 30], including functional limitations, fatigue, sleeping problems, and depressed mood [ 5] and significantly reduces quality of life [ 31].
In analyses controlling for demographic characteristics and comorbidity, subjects with OA and RA had poorer scores than those without arthritis on all HRQOL items, including general health, physical health, mental health, activity limitation, pain, sleep, and feeling healthy and full of energy.
