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Animal models could potentially overcome many of these limitations provided that tinnitus and hyperacusis can be reliably induced, behaviorally measured, and functionally imaged.
In contrast, the application of fluorescence-based sensors that provide quantitative readouts of kinase activity have considerable potential to overcome these limitations, provided that the challenges of sensor selectivity in complex mixtures can be adequately addressed.
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However, this limitation is due to our system maintenance and is not a theoretical limitation (provided that we can use a high-performance computer as our server).
The results imply that farmers in this part of Indonesia would be willing to abide by fairly strict limitations on land use, provided that they can be assured of long-term rights to the planted trees.
Nevertheless, provided that limitations are acknowledged and measurement methods are consistent pre- and post-scale-up, utilising proxy measures and actual data are more informative than entirely modelled estimates.
Nevertheless, in settings where resources and competency are available for direct measurement and provided that limitations of survey methods (such as recall and reporting bias) are recognised and minimised, direct measurement of proxy measures may be more informative and reliable than entirely modelled estimates.
Since the 1980s, human rights has articulated a series of principles – the Siracusa Principles – that indicate that that rights can be limited in service of public health provided that such limitations are both necessary and proportional [ 38].
Monitoring data, however, contain useful information provided that their limitations are understood and the data are used in an appropriate manner.
Provided that the limitations of the semiquantitative method are acknowledged, the use of spontaneous sputum therefore offers pneumology-specialized general outpatient clinics a simple and economic way to support the diagnosis of airway diseases by yielding clues on airway inflammation.
Such a limitation provides a guarantee that the monoubiquitylating E2 is kept from generating even small amounts of the polyUb chain on its AO7-targeted substrates.
Despite these limitations, those studies provided evidence that that FDG uptake has potential as a prognostic marker in breast cancer, which seems reasonable because tumors with increased glucose uptake show aggressive tumor behaviors and high proliferative propensities [ 8- 10].
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com