However, in spite of these limitations, proof-theoretic semantics has already gained very substantial achievements that can compete with more common approaches to semantics.
Due to space limitations, proofs of correctness of all of the claims in this section are deferred to Supplementary Materials.
The cross-sectional design has limitations; however, proof of concept was important and achieved (with a possibility of longitudinal follow-up).
There are several assumptions and limitations in this proof of concept study, many of which can be readily addressed.
Despite limitations, as a proof of principle pilot study, it may raise possibilities of further investigations on the role of IOP lowering potential of SLT in these challenging cases of glaucoma.
Although the solution structure (18) has been addressed in [5], the relationship among k, x k, and T is not well revealed due to the limitation of the proof procedure therein.
Although suggestive, the induction of Bkb expression by nitrate limitation is not proof that it can actually drive genome rearrangements by de novo insertion in the genome.
A limitation of our proof in Section 4 is that the complete-data variance estimator assumes that weights are known and ignores any estimation uncertainty about them.
Yet, with improved siRNA delivery technology and adenoviral vector systems that allow integration-independent transient expression of target genes at hand, it should be possible to overcome the limitations of our proof-of-principle approach.
Like all techniques, zebrafish xenotransplantation is not without its limitations, and additional proof-of-principle studies are needed to conclusively show that features that have made the mouse xenotransplantation model the 'gold standard' for preclinical studies, such as the ability for orthotopic engraftment and serial transplantation, are equally robust in the fish (Table 1).
In summary, despite the limitations of this proof-of-concept study (small sample size, short treatment duration and open-label design), IDegAsp was shown to be a promising new treatment option for initiating insulin therapy in subjects with type 2 diabetes inadequately controlled with OADs.
