Sentence examples for limitations on sequencing from inspiring English sources

Biological mosaicism and technological limitations on sequencing therefore prevent rigorous copy-number analyses as well as reliable junctional sequence data.

Inherent limitations on sequence alignment of short reads prohibit the detection of larger indels and, therefore, many potential disease-causing copy number variations (CNVs) are not accessible from TR data.

The small fetal DNA fraction in the maternal blood was the main limitation on sequencing dependent noninvasive prenatal diagnosis.

Due to limitation on sequence read length which is too small to span full-length retrotransposons, we were unable to identify these full-length elements.

A reason for the absence of any evolutionary conserved interactions may also be based on limitations of sequence alignment algorithms to accurately detect homologies between eukaryotic and Plasmodium specific proteins.

Despite these limitations on the sequences, for each one of them a large number of low-energy structures can be computed using all known models of the interactions that drive the folding process [8] [11].

The pneumococcal genome plasticity and inherent limitation of sequencing by hybridization approach resulted in 'no calls' on resequencing platform in several pneumococcal strains, especially in rapidly evolving variable gene sequences.

We chose this method because it is based on thermodynamic considerations of the 30S binding to the mRNA and overcomes the limitations of sequence analysis [ 13].

These results indicate that conclusions can be drawn at a variety of experimental scales, with deeper library coverage resulting in more power for some statistical analyses but with biological factors (for example, number and uniformity of specimens) eventually exerting the major limitations on interpretation as sequencing depth increases.

There are virtually no limitations on the pulse sequences that can be defined.

In any event, these results place certain limitations on the possible sequence of events that occur from absorption of a photon to posttranslational modification and ultimate proteolysis of type 1 CRYs.