While this does not pose a limitation on applications using relatively small probe sets, such as the 23 probes used in BRCA1 testing [ 12], where many exons are involved, such as DMD [ 13], or where screening is not targeted to single gene loci, probe sets of this magnitude would be inadequate.
The research aim is to determine the validity limits and limitations on the application scope of the finite element method in the masters and PhD students research.
This review reveals several knowledge gaps that impose significant limitations on practical applications of heat as a tracer of water flow.
The President's Proposal modifies these statutory provisions that currently limit random medical review and place statutory limitations on the application of Medicare prepayment review.
In the future the beneficial use of aerogels as catalysts or supports will depend on the progress made in both tailoring the surface chemistry of these solids and overcoming some technical limitations on their application.
It is commonly regarded that the active systems are superior to passive methods that operate without additional control units in some ways, but there are always limitations on the application due to reasons such as the cost of equipment, regular maintenance as well as reliability of the complicated integrated-systems.
In particular, there are limitations on the application of some of these methods to species with large, complex genomes.
Regarding antisense therapy, two problems with antisense nucleic acids, rapid decomposition and poor diffusibility in the cell membrane, impose limitations on its application to clinical treatment.
Limitations of application are also discussed.
Additionally, due to limitation of application of desmopressin on the area of the European Union, the second-line therapy in children with enlarged tonsils may involve its removal, while if these are not present or when surgical treatment does not lead to desired results, one shall consider orthodontic treatment.
