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In this Review we discuss the measurement, assessment, and benefits and limitations of trial endpoints in use for cancer treatment.
However, the limitations of trial duration and sample size in the current literature on the safety of IDeg preclude any results being able to be considered conclusive.
However, the variety in severity of symptoms, types of interventions, and limitations of trial methodology and reporting, suggest that the findings must be interpreted with caution [ 28, 12].
This issue highlights one of the limitations of trial data in this context: even the most comprehensive meta-analysis included substantially fewer patients than was possible in our study, and follow-up time ranged from 23 months to a maximum of five years, while 45% of patients in our study had at least five years of follow-up available.
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In order to surmount the above-mentioned limitations of trial-and-error process development, the so-called predictive models for mammalian cell culture processes are quite attractive [ 4].
However, our study also highlights the limitations of trials of service innovations.
Another limitation of trials comparing a relatively new treatment to the usual care is the risk of a potential nocebo effect; i.e. patients might feel disappointed after being allocated to the standard therapy.
The limitation of trials that may have excluded patients with comorbidity and multimorbidity was raised, as well as the potential value of routine observational data and social policy data.
Importantly, despite the inherent limitations of cross-trial comparisons, both trials essentially replicated the efficacy of the 'standard' bevacizumab regimens observed in E2100 and RIBBON-1.
In a press conference on Thursday, chief deputy state's attorney Michael Schatzow acknowledged the limitations of a trial for addressing the larger questions raised in the court.
The main limitations of our trial are that it only represented a very small group of patients.
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