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However, researchers and CCRs reported some structural limitations of the reference group meetings and also made positive suggestions how these could be improved for future projects.
Because correlations between the questionnaires and the reference instrument (i.e. the accelerometer) are interpreted as measures of the accuracy of the questionnaires, it is desirable to correct for limitations of the reference instrument that reduce these correlations.
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The potential limitation of the reference ontology is another source of concern.
We discuss the strengths and limitations of the different reference standards further below.
There are limitations to the reference-based approach.
There are strengths and limitations to each of the reference standards.
However it is important to note that the experts who are involved in making judgements and decisions about poorly performing doctors are aware of the limitations with the reference group data and take this into account.
In addition, these results show the limitations of single reference genome sequences as the only basis for characterization and cloning of resistance genes.
Apart from the discussed limitations of existing reference datasets often treated as gold standards, it would be problematic to evaluate the Lee and Lycett methods on the basis of the same gold standard data they received as input.
It goes on to identify the limitations of reference genomes and why choosing the closest relative is not always the best option.
Nonetheless, there are two principal limitations relating to the quality of the reference standard (a single radiologist's opinion) and a lack of blinding between the test and the reference standard, raising the potential for review bias.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com