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One of the limitations of functional gene arrays is that they cannot detect SNP-based or small indel-based mutations that affect virulence or resistance, because probes are selected to not be sensitive to small mutations.
The possible reasons for this finding will be discussed later in Limitations of functional hemodynamic parameters.
Since it is a clinical diagnosis, with an emphasis on limitations of functional capacity caused by dementia, it reflects the effect of the disease on the individual.
However, because of the limitations of functional assays, there is a strong argument that the primary emphasis should be on epidemiological evidence for its association with breast cancer risk [ 14].
The DLQI, the PSA, VAS, and the NPF are considered useful tools for the measurement of dermatology-related limitations of functional ability and the frequency, severity and impact of psoriasis symptoms on patients' lives and psoriasis-related quality of life.
The gender-specific limitations of functional capabilities are reported in figure 3. The highest prevalence of cognitive impairment was observed in males with CHF (23.0%) or COPD (24.6%) and in females with CHF (32.3%) or metastatic cancer (32.0%).
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The paucity of tools that control expression of specific genes in vivo represents a major limitation of functional genomics in mammals; most available small-molecule regulators of transcription e.g.g
Prior to the procedure, 12 patients (60%) had severe limitation of functional activities, 8 patients (40%) had moderate limitation of functional activities.
Post-procedure, ten patients (50%) had no functional limitations of activities, seven patients (35%) had minimal limitation of functional activities, two patients (10%) had moderate functional limitation, and one patient (5%) had marked limitation of functional activities (Fig. 3).
Post-operatively, 58.8% had no limitation of functional activities, 35.3% had minimal limitation of activities and 5.9% had moderate limitation of activities.
A potential limitation of functional testing, not only in our study, but also in other studies evaluating p53 functional assays, is that small clones can be missed.
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