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This may be especially useful for women at high-risk of breast cancer, where measurements of the extracellular miRNA composition might supplement other approaches, and overcome some of the diagnostic limitations of analyzing the cellular composition of lavages [95], [96].
However, apart from the recognised limitations of analyzing administrative databases [ 24], the patients in this study also had high levels of polypharmacy (≥ 70% to 93% of patients also received oral antipsychotics during depot therapy), suggesting extensive psychiatric comorbidity which may have had a negative impact on treatment retention [ 24].
Furthermore, despite the methodological limitations of analyzing data from different studies, the patient materials that we have access to are unique and are, to our knowledge, the best currently available for comparing symptom patterns in partial responders and treatment-naïve patients with GERD.
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Study limitations are obviously the small sample size of 14 subjects and the related limitation of analyzing multiple variables that may affect HRQoL.
The lack of a control arm has the inherent limitation of analyzing clinical data independently from the results of prior studies.
Because of limitations to analyzing paleontological data, the scientists can only say that the amount of energy in their sample of animals' remains is much lower than what it used to be.
However, there are limitations to analyzing exosomes with any of these methods.
On the basis of analyzing limitations of the classical analytical method, a comparative analysis of the numerical method is carried out.
Among this study's limitations was the impossibility of analyzing the utilization rates of FCLICs and FCHICs adjusted for age and sex.
The challenge that remains is to design new comprehensive and accurate bioinformatics tools capable of counterbalancing our limitations to analyze the overwhelming amount of genomic data generated.
In this regard, it is important to point out the intrinsic limitation of molecularly analyzing repetitive DNA elements, and so we used the complementary approaches of ChIP and 3D-FISH analysis to gain insights into the chromatin structure of D4Z4.
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