This perspective hopefully will rationalize the inevitable limitations of a preregistration trial database as a first step for ongoing surveillance to identify uncommon, rare, or slowly emerging adverse properties, including long-term risks of fatal, life-threatening, or permanently disabling events (13).
Although the women were recruited prospectively, there are potential limitations in the retrospectivity of a database.
In order to overcome those limitations, a database of ORFs was produced directly from the set of the whole-genome shotgun reads.
In contrast to recent studies, diabetes did not have an increased association with HCV+, perhaps due to limitations of the database.
In particular, because of the limitations of our database, we did not have information on why physicians prescribed an angiotensin receptor blocker instead of an ACE inhibitor as a first choice treatment.
The limitations of standard database techniques were overcome by adding knowledge to the retrieval system.
Please note that while the trigger eliciting the event-related features was set at the beginning of the stimulus, the time window considered to compute event related features encompassed the whole duration of the stimulus, plus 4 s (for a discussion on the duration of this time window please refer to Usage Notes and Limitations of the database, below).
This also indicates the limitations of the database, which does not present regional differences that would help researchers conduct further in-depth analysis and comparison.
As elaborated above, we recognize the strengths and limitations of this database.
However, several limitations of this database for the current study merit mention.
