We plan to escalate the total dose 42-45 Gy in three fractionation in case of favorable tumor sites, taking into consideration the limitation dose to normal tissues.
Thus, in the case of nickel limitation, dosing nickel can enhance methylotrophic methanogenic activity, without boosting acetogenesis.
Limitations include dose adjustment requirements, a relatively low genetic barrier to resistance, high price, and lack of data for use in children.
However, given tablet size limitations, the dose rates were not exact, and this was further compounded by changes in body weight during the study as well as the need for an occasional dose adjustment due to AEs.
Nanotechnology may provide an alternative means to overcome the limitation of dose escalation (radiosensitizers, radioisotopes) and physical-technical features (IGRT) that can be manipulated to further improve treatment efficacy.
First, the dimension of the analysed object cannot be larger than a human body and also the material has not to be too dense; moreover, due to the limitation on dose which can be delivered in a medical CT, the signal is typically quite low and for this reason the resolution limited.
While limitations of dose-response functions have been described for these agents, there are also significant limitations and uncertainties about other aspects of QMRA, including exposure assessment.
Alternatively, the potential efficacy and biomarker effects of the antibodies may not have manifested due to limitations in dosing levels or frequency and the failure to achieve efficacious brain concentrations.
In contrast to extremity sarcoma, postoperative radiation therapy (RT) has shown limited efficacy due to its limitations in achievable dose and coverage.
We felt that our limitation to doses < 5 mg/kg BW/day was adequate to ensure relevance of the animal dose response estimates to humans.
