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The antiangiogenic contribution of IL-12 together with its immunomediated antitumor properties were consistently studied and reported previously [ 32, 34, 35, 43, 60], as well as its limitations as a single antitumor agent [ 36].
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Our study has several limitations as a single-center, retrospective, observational study.
While traditional protein tagging systems are limited to protein isolation and purification, the HaloTag system has overcome this limitation, as a single genetic construct allows proteins to be comprehensively analyzed.
Despite its limitation as a single institution study, this study speaks to a fundamental problem of disparities in breast cancer outcomes among African American women.
While the pilot study was encouraging, it had limitations such as a single-blind design.
However, these ratios illustrate the limitations of mortality as a single outcome parameter, particularly at young ages and in women, and emphasise the need to include non-fatal outcomes in estimations of the risk of cardiovascular events.
In view of the limitations of tamoxifen as a single modality treatment, attention has switched to the neoadjuvant use of endocrine therapy to increase the rate of breast conservation [ 21].
A methanol-tolerant cathode electrode composed of heterogeneous composites was developed to overcome CO poisoning and large O2 mass transfer overpotential generated by methanol crossover as well as the limitation of a single alloy catalyst with methanol-tolerance in direct methanol fuel cells (DMFCs).
They argue that cooperative spectrum sensing can be used to tackle the sensing limitations of a single vehicle as it exploits spatial diversity.
Because of these limitations, relying on CFR as a single measure of the effects on a population may make an assessment difficult if such data are not yet available early in a pandemic or misleading if the available data are not well characterized and the biases are not well understood.
As for limitations, this is a single sample from one institution of higher education; greater use among more and diverse educational institutions would help to re-affirm the reliability of the initial findings presented here.
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