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In England there is no general statute of limitations applicable to criminal actions, although statutes for specific crimes frequently have included time limits.
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An additional potential limitation applicable to all observational studies is the possibility for residual or uncontrolled confounding.
One potential limitation applicable to all studies that so far evaluated the relationship between iFR and FFR is the fact that all hemodynamic analyses were performed offline.
1 2 7 8 9 10 11 12 13 14 15 An important limitation applicable to previous comparative analyses is that most of the observational studies did not have rigorous inclusion and exclusion criteria, exposure definitions, and outcomes identical to the randomised controlled trials so that lack of randomisation was not the only important difference.
The same limitations are applicable to the data reported in Figure 8 on spinal cord sections from wild type and knockout mice.
This latter limitation is applicable to many validated patient-centred outcome measures.
Difficulty visualizing non-enhancing tumor burden is a problem for most proposed methods of assessing tumor response, and some authors have advocated that response criteria in these situations may have to be altered to include both radiologic changes and measurements of circulating biomarkers.[39] Unfortunately, these limitations are equally applicable to the Macdonald or RECIST criteria.
These limitations are especially applicable to studies conducted in remote locations, as well as areas of intense seasonality.
These limitations are frequently applicable to datasets collected from prospectively recruited patients, but the use of routine data sources also may present problems relating to availability, accuracy, and completeness (36).
However, this limitation is not applicable to the suite of estrogens used in this study.
However, this limitation was not applicable to the VC, where all patients underwent an anatomically defined ePLND regardless of the risk of LNI.
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