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Because in vitro antifungal testing has limitations, animal models remain the essential tool to understand virulence and to optimize antifungal therapies.
Despite their limitations, animal models remain fundamental to improving our understanding of human ARF [ 28- 30].
Despite these limitations, animal models will continue to have a considerable role in the study of ALI, because few alternatives allow investigation and therapeutic testing in a complex biological system.
Contact: [email protected] Despite their limitations, animal models play an essential role in biomedical research, ranging from basic science to translational medicine, as human testing is severely limited by practical and ethical constraints.
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Study limitation: Animal serum is a complex mixture of a large number and variety of components; therefore, it is difficult to assess, at this stage, the significance of the observation that horse serum inhibits the programmed progress of equine airway cells through the lineage of differentiation in cultures.
These regulatory values may overestimate the disease burden given the limitations of animal testing and the assumptions required to extrapolate toxicity data from animals to humans (e.g., applying uncertainty factors).
The signatories want to help the public better understand the benefits, costs, and limitations of animal research through a "realistic" description of the expected results, the impact on animals' welfare, and ethical considerations.
Given the rapid growth of the B16F10 model and ethical limitations of animal studies, studies using this pre-clinical mouse model is limited typically to a single round of therapy.
Limitations of animal infection models have engendered longstanding obstacles in basic science and translational research.
Language is a uniquely human trait, which poses limitations on animal models for discovering biological substrates and pathways.
It highlights the keystone place of tree foliage in this system, even though this type of forage resource is reputed to present several limitations for animal nutrition.
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