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By definition, the current review is an overall analysis which involves, as a major limitation, the problem of bias in selection.
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Many efforts were directed to efficiently alleviating the PAPR problem [3 6], but because of either some standard-compatibility issues or some practical system limitations the problem is not yet considered as completely solved [7].
Many other neuropsychological tests that evaluate EF are used in the diagnosis of MCI. 10, 11 However, most of these tests have numerous limitations (the problem of novelty, lack of sensitivity and specificity, patient cognitive reserve, etc).
Another clear limitation is the problem of multiple testing that may lead to spurious P-values and it is noteworthy that out of the all variants examined here, only associations with the TIMELESS variants rs7486220 in females and rs1082214 in males sustain after correction for the multiple testing.
One potential limitation is the problem of demand characteristics.
One remaining limitation is the problem of document interpretation.
This solution has a more fundamental limitation since the problem is often not simply the absence of one or two dimensions.
Another possible limitation is the problem of recall [ 28] or, perhaps the respondents found it impossible to prioritise the elements and thus opted for 'don't know' or left the free-text blank.
Thus, by replacing these values in the objective function and considering the limitations of the problem, a linear programming problem is formed.
In addition, the steps of this procedure are such that it can be implemented by hand and have no limitations on the problem size.
However, even imaging has its limitations, including the problem of "disappearing liver metastasis," which are increasingly noted after neoadjuvant chemotherapy.
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CEO of Professional Science Editing for Scientists @ prosciediting.com