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The detection limitation (sensitivity) was ≤ 10 copies of in vitro transcribed RNA for pan-enterovirus real-time RT-PCR [ 27].
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Although the limited number of available studies and the large heterogeneity between studies were considerable limitations, sensitivity analyses demonstrated that results were not strongly affected.
Tuberculin skin test (TST) has several limitations: sensitivity may be influenced by the child's age and immunologic status, bacille Calmette-Guérin (BCG) vaccination or non-tuberculosis mycobacterium-infections; in case of repeated tests a booster effect can occur and a double access to a health care facility is needed.
To address the uncertainty associated with this limitation, multivariate sensitivity analysis using a combination of probabilistic sensitivity analysis and bootstrapping was used.
Despite their great potentiality, ISFET-like devices generally suffer from an intrinsic limitation in sensitivity, the so-called Nernst limit.
But the drawback is the limitation of sensitivity and dynamic range (Wolfender et al., 2015).
Given the limitation in sensitivity in detecting small cholesteatoma less than 3 mm, serial monitoring with DWI over time is recommended to allow any small residual cholesteatoma pearls to grow and become large enough to be detected on DWI.
This profound limitation in sensitivity can be overcome by enzymatically releasing the exact SHL8 peptide from its embedded location within the polypeptide sequence.
However, NMR's major limitation is sensitivity.
To address this limitation, a sensitivity analysis was conducted by increasing the complication rate from 3.8%to15%5%.
The limitation of sensitivity can be resolved by reducing the dimensions to the nanoscale.
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