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18F-MK-9470 produces radiometabolites, which limit the specificity of the tracer for imaging CB1R in a peripheral setting [30].
Therefore, the analysis was focused on these groups of patients to identify other risk factors not included in the L-ARRCO score that limit the specificity and sensitivity of the score.
It may also limit the specificity and selectivity of aptamer targeting because of steric hindrance between the target tumor cells and the nanoparticles, such as when aptamer DNA "lies down" on the nanoparticle surface [27].
These characteristics limit the specificity of these tracers for actual tumour cell proliferation.
Several studies have shown that tuberculosis can produce high F-FDG uptake and limit the specificity of F-FDG PET/CT scans by mimicking metastases [ 11, 12, 16, 22, 23].
On the other hand, F-FDG accumulates not only in malignant adrenal tumours but also in 5 – 10%% of benign tumours that mimic metastasis and limit the specificity of F-FDG PET/CT imaging.
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25 26 Sex-specific estimates of RR at varying levels of alcohol consumption were available only for hypertensive disease and liver cirrhosis, and no age-specific estimates were available, which limits the specificity of the counterfactual scenarios analysed by the model.
Despite the sensitivity of dynamic contrast-enhanced imaging for the detection of progressive tumours after ablative therapy, areas of residual benign prostatic hypertrophy may show hypervascularity, thereby yielding false-positive findings and limiting the specificity of dynamic contrast-enhanced imaging [63].
However, other reports noted that cross-reacting antibodies from infection with other subtypes limited the specificity of the assay [35] [37].
This limits the specificity of IL-18 in the setting of mixed AKI and pronounced inflammation.
Moreover, we did not include a clinical comparison group, which limits the specificity of the present findings.
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