Polypills improve adherence, are generally well tolerated, and reduce risk factor levels, although heterogeneity limits the certainty of the effect on risk factors.
However, they only reported case summaries of the data, indicating what percent of the cases increased or decreased relative to baseline and, therefore, limiting the certainty of their conclusions.
Lastly, the cross-sectional nature of this analysis limits the certainty of inferences regarding the observed temporal-and dredging-associated differences in serum PCB levels.
Second, the small number of patients in each treatment group, especially in the insulin group, limited the certainty with which we could formulate conclusions regarding aspirin's effect.
Moreover, the lack of a reliable diagnostic gold-standard for IFD in the absence of histological samples and the heterogeneous clinical presentation of the disease limit the diagnostic certainty in the majority of cases.
Nonetheless, the amount of ECOG data available was relatively limited, so the certainty and magnitude of the identified effect should be interpreted with caution.
The young people of this country, to whom I dedicated the book, have limited job prospects, the certainty of debt, housing that may be beyond their means for a lifetime and, if pensions and the NHS progress as at present, no chance of a secure old age.
They were limits which Alexis highlighted and exploited in their work, and limits which they rejected, along with the certainty of fixed gender identity and other kinds of black-and-white thinking.
While trying to be as sympathetic as possible, I find myself reminding Lucy of the limits of certainty in medicine.
I've been drawn to people who recognize the limits of certainty and do not speak in absolutes and who spend more time listening than making pronouncements".
