8 The HTA Journal is therefore not as likely to be affected by publication bias as other health research literature, which could therefore limit ratings of relevance and newsworthiness when compared to other journals.
In clinical trials, medium-effect sizes (d = ~0.5) are usually considered the lower limit of clinical relevance.
The limit of clinical relevance was set to 0.7, and agreement between both methods was concluded when the 95% confidence interval (CI) for the agreement rate was positioned above 0.7.
The C-peptide concentration of 0.04 nmol/L was chosen as the cutoff for RBF when considering RBF as a dichotomous outcome (with or without RBF) because it was shown in the DCCT (7) to be the lower concentration limit of clinical relevance in adults.
Trapping isotherms obtained at different temperatures displayed non-linear course in the range up to the upper limit of the analytical relevance of 100 ng of an analyte, indicating a limited trapping capacity of the modified graphite surface and the same trapping mechanism at low and elevated temperatures applied (300 1300 °C).
However, the small number of enrolled patients and the absence of placebo group, complete blinding, and baseline characteristics of the population seriously limit the relevance of this trial.
The major drawbacks in atherogenesis research are (i) difficulties in investigating the early phase of the pathology in the clinical context and (ii) discrepancies between experimental models and human characteristics of the disease, which can limit the relevance of results.
Alterations in the random fraction, although not measured in our study, could affect the reliable mathematical description of the non-random one, something that might limit the relevance of these results [ 24].
Increasing clindamycin resistance observed in recent outbreaks [ 1] may limit the relevance of this study in some regions, necessitating evaluation of alternative protein synthesis inhibitors.
As has already been said, the trouble with the analysis of Mussa and Rosen (1978) rests in its differentiability assumptions that limit the relevance of the results achieved.
