limit of quantitation

USAGE SUMMARY

The phrase "limit of quantitation" is correct and usable in written English.
It is typically used in scientific and analytical contexts to refer to the lowest concentration of a substance that can be reliably measured by a particular analytical method. Example: "The limit of quantitation for this assay is 0.1 ng/mL, ensuring accurate detection of the analyte in samples."

✓ Grammatically correct

Science

Human-verified examples from authoritative sources

Exact Expressions

60 human-written examples

BLQ, below the limit of quantitation.

Nature

Values below the lower limit of quantitation (BLOQ) were inputted as half of lower limit of quantitation (LLOQ/2)53.

Nature

The lower limit of quantitation was 20.0 pg/mL.

Journal of Pharmaceutical and Biomedical Analysis

The alliinase protein levels in #6 and #10 bulbs were below the limit of quantitation of the ELISA (Fig. 6A).

Nature

The lower limit of quantitation, at which the relative standard uncertainty is 10%, is 2.3 mM.

Electrochimica Acta

lower limit of quantitation.

AAPS Open

below the limit of quantitation.

AAPS Open

Identification for the limit of quantitation of this assay.

Chemistry Central Journal

LOD, limit of detection; LOQ, limit of quantitation.

Environmental Sciences Europe

Where limit of quantitation ranged between 0.1-1 pg/mg.

Chemistry Central Journal

The limit of quantitation was 0.25 ng/mL.

Chemistry Central Journal

Expert writing Tips

Best practice

When reporting data, clearly state the "limit of quantitation" for your assay to ensure transparency and allow others to assess the reliability of your results.

Common error

Avoid interchanging "limit of detection" (LOD) and "limit of quantitation" (LOQ). LOD refers to the lowest level at which a signal can be reliably detected, while LOQ is the lowest level at which the substance can be reliably quantified with acceptable accuracy and precision.

Linguistic Context

The phrase "limit of quantitation" functions as a noun phrase, specifying a particular threshold in measurement. It is primarily used in scientific and analytical contexts, as supported by the Ludwig examples.

Expression frequency: Very common

Frequent in

Science

100%

Less common in

News & Media

0%

Formal & Business

0%

Academia

0%

Ludwig's WRAP-UP

The phrase "limit of quantitation" is a noun phrase widely used in scientific and analytical domains to denote the lowest concentration of a substance that can be reliably measured. Ludwig AI confirms its grammatical correctness and frequent use, with the majority of examples stemming from scientific publications. It’s crucial to distinguish the "limit of quantitation" from the "limit of detection", with the former representing the threshold for reliable quantification and the latter for mere detection. In data reporting, stating the "limit of quantitation" is considered a best practice for transparency and validity.

More alternative expressions

Phrases that express similar concepts, ordered by semantic similarity:

Quantification limit

Reorders the words while maintaining the original meaning; emphasizes the 'quantification' aspect.

Lower limit of quantification

Specifies that it's the lowest value that can be measured, adding precision.

Limit of quantification (LOQ)

Adds the acronym commonly used for this measure, for clarity.

Minimum quantifiable level

Uses different wording emphasizing the level aspect.

Quantifiable threshold

Replaces 'limit' with 'threshold', which has a similar meaning in this context.

Lowest quantifiable concentration

Replaces 'level' by 'concentration', specifying the measure's metric.

Assay sensitivity limit

Focuses on the assay's capability to detect and quantify the substance.

Detection and quantification threshold

Highlights both the detection and quantification aspects of the measurement.

Reliable measurement threshold

Emphasizes the reliability of the measurement.

Sensitivity of quantification

Focuses on how sensitive the method is for quantification

FAQs

How is the "limit of quantitation" determined?

The "limit of quantitation" is typically determined through statistical analysis of calibration curves, considering factors like signal-to-noise ratio, precision, and accuracy. Commonly, the ICH guidelines are followed.

What does it mean when a value is reported as below the "limit of quantitation"?

When a value is below the "limit of quantitation" (BLQ), it means the concentration of the substance is too low to be reliably measured by the assay. It doesn't necessarily mean the substance is absent, just that its concentration is below the quantifiable range.

How does the "limit of quantitation" differ from the "limit of detection"?

The "limit of detection" (LOD) is the lowest level at which a substance can be reliably detected, even if it can't be accurately quantified. The "limit of quantitation" (LOQ) is the lowest level at which a substance can be both reliably detected and accurately quantified. LOQ is always higher than LOD.

Why is it important to know the "limit of quantitation"?

Knowing the "limit of quantitation" is essential for assessing the reliability and accuracy of measurements. It helps researchers and analysts understand the range within which their data is valid and interpretable. Reporting values below the LOQ can lead to inaccurate conclusions.