limit of quantification

USAGE SUMMARY

"limit of quantification" is a correct and commonly used phrase in written English.
It refers to the lowest concentration or amount of a substance that can be accurately measured by a specific analytical method. Example: The sensitivity of the new laboratory equipment was impressive, with a limit of quantification of just 0.001 nanograms per milliliter.

✓ Grammatically correct

Science

Human-verified examples from authoritative sources

Exact Expressions

60 human-written examples

The lower limit of quantification was 0.25 ng·mL−1.

Chinese Journal of Natural Medicines

The limit of quantification validated was 1 ng/mL.

Analytical Chemistry Research

The validated lower limit of quantification was 1 ng/ml.

Journal of Pharmaceutical and Biomedical Analysis

The lower limit of quantification (LLOQ) was 1.0 ng/ml.

Journal of Chromatography B

The limit of quantification was 0.1 ng ml−1.

Journal of Chromatography B

Lower limit of quantification.

Chemistry Central Journal

Limit of quantification.

Clinical and Translational Medicine

the limit of quantification.

Chemistry Central Journal

Lower limit of quantification for quality control.

Chemistry Central Journal

The limit of quantification was 70.0 μg L−1.

Journal of Analytical Science and Technology

The lower limit of quantification (LLOQ) was 2 μg/ml.

Nano Convergence

Expert writing Tips

Best practice

Clearly distinguish between the "limit of quantification" (LOQ) and the limit of detection (LOD). LOQ is the lowest level at which the analyte can be reliably quantified with acceptable accuracy and precision, while LOD is the lowest level at which the analyte can be detected but not necessarily quantified.

Common error

Avoid using the limit of detection (LOD) when the limit of quantification (LOQ) is more appropriate. LOD indicates mere detectability, while LOQ signifies reliable measurement. Using LOD when LOQ is required can lead to misinterpretations of data and unreliable conclusions.

Linguistic Context

The phrase "limit of quantification" functions as a noun phrase that typically acts as a subject complement or object of a preposition. As Ludwig AI indicates, it specifies the lowest concentration of a substance that can be reliably measured by an analytical method.

Expression frequency: Very common

Frequent in

Science

100%

Less common in

News & Media

0%

Formal & Business

0%

Ludwig's WRAP-UP

In summary, "limit of quantification" is a noun phrase denoting the lowest concentration of a substance that can be reliably measured. Ludwig AI confirms that it's a grammatically correct and commonly used phrase, especially within scientific and technical contexts. Its primary function is to define a boundary of reliable measurement in analytical procedures. It maintains a formal and scientific register, predominantly appearing in scientific literature. The phrase is very frequent in scientific documents.

When using this phrase, ensure you specify the analytical method, matrix, and units of measure for clarity. Distinguish it from the "limit of detection" to avoid misinterpretations. With these guidelines, you can confidently employ "limit of quantification" in your scientific writing.

More alternative expressions

Phrases that express similar concepts, ordered by semantic similarity:

quantification limit

Reverses the order of the words while retaining the core meaning.

lower limit of quantification

Specifies the direction of the limit, indicating the lowest quantifiable value.

quantifiable limit

Changes the structure to emphasize the limit as something that can be quantified.

level of quantification

Substitutes "limit" with "level", focusing on the degree of quantification.

minimum quantification level

Emphasizes the minimum level at which quantification is possible.

detection threshold

Indicates the boundary at which something can be reliably detected and measured, often related but not identical.

quantitation threshold

Uses the term "quantitation" instead of "quantification", slightly altering the emphasis.

measurable quantity threshold

Replaces "quantification" with a more descriptive phrase, highlighting the measurable aspect.

lowest quantifiable concentration

Focuses on concentration as the quantifiable aspect.

assay sensitivity limit

Indicates the limit of how sensitive an assay is, altering the context slightly.

FAQs

How is the "limit of quantification" determined?

The "limit of quantification" is typically determined through a validation process involving the analysis of samples with known concentrations of the analyte. It's often defined as the lowest concentration that can be quantified with acceptable precision and accuracy, typically assessed by calculating the standard deviation of replicate measurements.

What's the difference between the "limit of quantification" and the "limit of detection"?

The "limit of quantification" (LOQ) is the lowest concentration of an analyte that can be reliably measured and quantified with acceptable accuracy and precision. The "limit of detection" (LOD), on the other hand, is the lowest concentration at which the presence of an analyte can be reliably detected, but not necessarily quantified.

Why is it important to know the "limit of quantification"?

Knowing the "limit of quantification" is crucial for ensuring the reliability and accuracy of analytical measurements. Reporting values below the LOQ can lead to inaccurate or misleading conclusions, especially in fields like environmental monitoring, pharmaceutical analysis, and clinical diagnostics.

What can I do if my sample concentration is below the "limit of quantification"?

If your sample concentration is below the "limit of quantification", you can report it as 'below LOQ' or 'less than LOQ'. Alternatively, you might consider using a more sensitive analytical method, increasing the sample volume, or pre-concentrating the sample to bring the analyte concentration above the LOQ.