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In this view, cells are so robust that they do not limit life span.
Limited life span and senescence are universal phenomena, controlled by genetic and environmental factors whose interactions both limit life span and generate variation in life span between individuals, populations and species.
Furthermore, as discussed below, TOR negatively regulates mitochondrial gene expression to limit life span [ 37].
In humans (and other mammals), age-related diseases are manifestations of aging that actually limit life span.
But although molecular damage accumulates, it does not necessarily limit lifespan, particularly if other causes limit life span.
Since aging does not limit life span in the wild, switch-off of this 'growth program' cannot evolve.
Similar(49)
There is a class of theories of aging (variously termed adaptive aging, aging by design, aging selected for its own sake, or programmed death theories) that hold that an organism design that limits life span conveys benefits and was selected specifically because it limits life span.
While surgical options such as RV to pulmonary artery (PA) conduit have limited life span, balloon angioplasty and bare-metal stenting is complicated by development of free pulmonary regurgitation [59].
The primary MSCs have limited life span with an average number of population doublings of 38 and tend to change their differentiation potential during in vitro expansion [24].
In other words, TOR limits life span by accelerating age-related diseases.
By the same token, "aging" due to molecular damage will not manifest itself, if aging due to hyperfunction invariably limits life span [ 122].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com