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However, a major disadvantage to passive immunization for chronic neurodegenerative disorders would be the need for multiple infusions and the risk of developing anti-idiotypic immunity, which would limit efficacy and be associated with toxicity.
These agonist effects may, however, limit efficacy.
Due to facial paresis, severe air leaks may limit efficacy and tolerance.
Chlorophyll can limit efficacy of carcinogens, such aflatoxin B1 [ 32- 36] and can activate Phase II detoxifying enzymes [ 37].
It may have limit efficacy in very severe strokes, particularly in cases of extensive brain damage [ 20, 21].
Poor drug distribution and short drug half-life within tumors strongly limit efficacy of chemotherapies in most cancers, including primary brain tumors.
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Some of the new cancer drugs hold immense promise, but others have limited efficacy and are exorbitant.Nevertheless, a rational debate is elusive.
Monotherapy with nortriptyline has limited efficacy.
However, RFA has limited efficacy and is quite expensive.
But it had limited efficacy against dengue 2, one of four dengue virus serotypes in circulation.
Currently available treatments for autoimmune diseases, such as steroid and nonsteroid immunosuppressive medicines, have limited efficacy.
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