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Since their study included US LIM animals, it is possible that these LIM animals were not pure-bred animals, unlike the LIM animals we used.
Gautier and collaborators found in their study that HOL is also the most differentiated breed; however they found that AUB and LIM animals shared the smallest FST (FST = 0.0353) [ 42].
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The potential nuclear targeting signal (KKYGPK) present in the CRP family of animal LIM proteins is also missing in the plant LIM domain family.
Like lim-6 mutant animals, ot108 mutant animals show derepression of the ASER marker gcy-5 in ASEL, while gcy-7 expression in ASEL is unaffected.
Although the LIM domains from animal CRP proteins are structurally similar to the GATA-type zinc finger transcription factor, their DNA-binding activity is yet unproven and CRP may rather be involved in protein protein interactions.
As for animals, plant LIM proteins may have a function in the regulation of cell differentiation or development.
HFS of the vmPFC has not only been demonstrated for memory enhancement in the middle-aged memory deficit rat model, but also induced profound antidepressant-like behaviors in the experimental animal studies (Lim et al., 2015a; 2015a).
Calcium retention for animals fed diet LIM was higher than those fed either or diets CTP and LUC.
Compared with the CRP family in animals, the second LIM domain in plants is atypical with the second ligand of the second zinc finger replaced by a conserved glycine.
This is the case for the GRR following each LIM domain found in the animal CRP proteins that lacks in all the plant LIM domain proteins.
The cysteine-rich protein (CRP) family in animals is a subclass of LIM proteins characterized by their two LIM domains, with the consensus sequence [C-X2-C-X16 23-H-X2-C]-X2-[C-X2-C-X16 21C-X2 3-(C/D/H)], that are both followed by a short glycine-rich repeat.
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