Sentence examples for likeness properties from inspiring English sources

It confirms the drug likeness properties of these compounds.

Additionally, both derivatives showed no considerable toxicity in neuronal cell viability assay and represented drug likeness properties in the primarily pharmacokinetics study.

Physicochemical parameters of the synthesized compounds were in-silico predicted in order to evaluate their drug likeness properties using Qik-prop 3.7 [20] module of Schrödinger and online tool AdmetSAR [21].

So in our study, physicochemical parameters of the synthesized compounds were in-silico generated in order to evaluate their drug likeness properties using Qik-prop module of Schrödinger and online tool AdmetSAR (Table 2).

Importantly, the compounds evidenced drug-likeness properties, including good membrane permeability.

The problem may be related, among others, to their non-drug-likeness properties.

From this study, about 400 compounds have been identified from African flora and their drug-likeness properties evaluated in comparison with NPACT and DNP.

Herein, a series of aminobenzo[b]thiophene 1, 1-dioxides with good drug-likeness properties were designed, synthesized and evaluated as STAT3 inhibitors.

Alternatively, if pharmacophores present different structural elements required for the interaction with each target, they can be conjugated with cleavable or non-cleavable linkers, although this strategy often leads to molecules with poor drug-likeness properties [41].

13065_2017_364_MOESM1_ESM.docx Additional file 1. Predicted ADME (Drug-likeness) properties of all synthesized compounds and selected copies of spectrum (1H/13C-NMR, MS and HRMS) for synthesized some benzimidazole derivatives are provided in supporting information.

Lead optimization of the synthesized compounds was done by computation of drug-likeness properties molecular weight, partition coefficient i.e., log P, hydrogen bond donors (HBA), and hydrogen bond acceptors (HBD).